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MSC is a colourless liquid that dissolves in polar organic solvents but is reactive toward water, alcohols, and many amines.
A key reagent for a wide range of applications in chemical synthesis, it is used in pharmaceuticals, agrochemicals, dyes and pigments.
MSC is an excellent protecting group for alcohols and amines and can be used for the synthesis of carbohydrates. MSC is very effective in generating good leaving groups, it can also be used as chlorinating agent, as a carboxylic acid activating agent, in the synthesis involving inversion of lactones or in the preparation of boronic esters.
Methanesulfonates are often employed in substitution, reduction and elimination reactions.
Oxon’s continuous production process runs under DCS system to grant consistent purity and top-level quality. Oxon’s MSC production site, the only one in Europe, is strategically located in northern Italy, allowing quick and safe reach of all customers with bulk or drums delivery despite product hazardous classification for storage and transport
Alternative Name: mesyl chloride.
Physical Data: bp 60 °C/21 mmHg; d 1.480 g cm-3.
Solubility: insol water; sol alcohol, ether.
Handling, Storage, and Precautions: highly toxic; corrosive; lachrymator; moisture sensitive; store in a cool dry place.
A colourless hygroscopic liquid that freezes around 20 °C almost insoluble in non-polar solvents such as hexanes and benzene/toluene.
Oxon produces MSA 70% and high quality MSA anhydrous 100% in two grades: Industrial and Pharma grade.
Alternative Name: methylsulfonic acid, MsOH
Physical Data: mp 20 °C; bp 167 °C/10 mmHg, 122 °C/1 mmHg; d 1.481 g cm-3; n 20D 1.3210.
Solubility: soluble in water, ethanol, ether; insoluble in hexane; very sparingly soluble in benzene, toluene.
Handling, Storage, and Precautions: irritant and highly corrosive liquid; should be stored in glass containers.
Suitable for all kind of chemical synthesis involving MSA (rearrangement and condensation reactions), catalyst or to produce mesylates (amines salification).
Pharmaceutical industries use anhydrous MSA as intermediate, catalyst and solvent. Oxon Anhydrous Pharma grade product is particularly suitable for all those synthesis of APIs which require an extremely low and controlled level of alkyl esters.
Aqueous 70% methanesulfonic acid is mainly used in surface cleaning, as supporting electrolyte in electroplating baths, catalyst for polymerization and as reagent in leather treatment.